Simpson works in various media including sculpture, painting, and photographic collage. She usually incorporates images found from vintage magazines, which focused on chronicling black lives and provided a representation of African-American culture that was lacking in other media. That material has both a personal and cultural significance for Simpson who describes how the magazines, “informed my sense of thinking about being black in America and are both a reminder of my childhood and a lens through which to see the past fifty years of history.”

Her photographic collages reconfigure imagery of the female form and reflect the artist’s ongoing exploration of contemporary culture and American life. Unanswerable (2018), an installation composed of a variety of photo collages represents a series of female protagonists integrated with animals, architectural features, and natural elements to create scenarios that are at once poetic and arresting. In this way, Simpson deftly suggests compelling new narratives that emerge from the unexpected settings and contexts. She uses natural elements such as ice blocks as a metaphor to represent confinement or isolation from wider society.